Cayce (/ˈkeɪsi/ KAY-see)[6] is a city in the U.S. state of South Carolina, along the Congaree River.

[10] Cayce is part of the Columbia Metropolitan Statistical Area and is within South Carolina's Midlands region.

[12] Spanish explorer Hernando de Soto reached the area in 1540, encountering a large Native village at Congaree Creek, where Cayce now stands.

[12][13] The Guignard Brick Works were established on the west bank of the Congaree in 1803 and remained active for nearly two centuries.

[11] The town includes the area that was once Granby, at one time the county seat and a flourishing community before it was abandoned by the end of the first quarter of the nineteenth century.

In December 2007, the city council voted to annex a 3,100-acre (13 km2) floodplain in Richland County.

[15] The city planned to develop the annexed area, but after significant evaluations the city abandoned the project after determining that development was not suitable in the flood-prone area, leaving Cayce with a sizeable piece of sparely-populated land.

All of its public attractions, with the exception of the Cayce Historical Museum, are free of charge.

[24] Public transportation in Cayce is provided by the COMET, or officially the Central Midlands Regional Transit Authority (CMRTA).

[28] As of the 2020 United States census, there were 13,781 people, 6,017 households, and 2,794 families residing in the city.