Cayo Agua (Water Cay) is the eastern and southernmost island in the Bocas del Toro Archipelago, Panama, separating Chiriquí Lagoon in the south from the Caribbean Sea in the north.

It has a surface area of 16 km2.

[1] The island is part of the Bocas del Toro Important Bird Area (IBA), designated as such by BirdLife International because it supports significant populations of white-crowned pigeons and three-wattled bellbirds.

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