The West Branch of Cazenovia Creek rises from sources in the towns of Colden, Concord, and Sardinia.

Cazenovia Creek is named after Theophilus Cazenove, an agent of the Holland Land Company.

In 1897, landscape architect Frederick Law Olmsted drew up plans for a park near the south city line of Buffalo.

Cazenovia Creek is known for its annual ice jams in the early spring when temperatures rise.

Species include catfish, large and small mouth bass, and rainbow and brown trout.