Cefpodoxime is an oral, third-generation cephalosporin antibiotic available in various generic preparations.

It is active against both Gram-positive and Gram-negative organisms with notable exceptions including Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.

It is typically used to treat acute otitis media, pharyngitis, sinusitis, and gonorrhea.

Cefpodoxime inhibits peptidoglycan synthesis in bacterial cell walls.

Toraxim (by Delta Pharma Ltd., Bangladesh) Trucef (by Renata Limited, Bangladesh) Tricef (by Alkaloid Skopje, North Macedonia) Orelox (by Sanofi-Aventis)[6] MAPDOX-CV: Combination cefpodoxime–clavulanic acid[by whom?]