The President Biden Expressway begins at an interchange with US 11/PA 307 and Cedar Avenue in Scranton, with access to northbound US 11/PA 307 and from southbound US 11/PA 307.

[5] The road was built along a portion of the former Lackawanna and Wyoming Valley Railroad right-of-way passing beneath the Harrison Avenue Bridge.

[6] It opened[year needed] with a temporary western terminus feeding into Front Street at Prospect Avenue.

the current interchange at the western terminus was opened, connecting to a new road replacing the demolished Spruce Street Bridge.

[2][9] In December 2024, local residents and multiple state politicians called for Biden's name to be removed from the expressway after he controversially commuted the sentence of Michael Conahan, a judge responsible for the kids for cash scandal that took place in neighboring Luzerne County.