The intralaminar thalamic nuclei (ITN) are collections of neurons in the internal medullary lamina of the thalamus.

[1] The ITN are generally divided in two groups as follows:[1] Some sources also include a "central dorsal" nucleus.

Midline intralaminar nuclei receive afferents from the brain stem, spinal cord, and cerebellum.

Afferents from the spinothalamic tract as well as periaqueductal gray are part of a pathway involved in pain processing.

One postmortem study of patients with closed head injuries showed correlation of the involvement of these nuclei with the various degrees of disability.