In January 2004, Centrebus acquired the St Albans operation of Blazefield although in March 2008 it was sold to Uno.

[5] In June 2007, Centrebus purchased Bowers Coaches,which through a joint venture with Wellglade Group became High Peak Buses in 2012.

In April 2012 Centrebus transferred the business into a joint venture with the Wellglade Group to form High Peak Buses with Bowers operations relocated to Trent Barton's Dove Holes depot.

In September 2008, Centrebus purchased the local bus operations of the Woods Coaches, Leicestershire business.

[14] In August 2010 Centrebus took over the operations of Judges Mini Coaches, Corby with routes serving Kettering, Milton Keynes, Welford, Wellingborough, Wicken and Yardley Gobion.

In October 2011 Centrebus purchased Paul James Coaches,[16] Saxby from Veolia Transport with 21 buses.

[21] The remaining routes moved to the Stevenage depot, allowing the business to consolidate its East Hertfordshire operations on a single site.

[25] Centrebus are currently rolling out a revised livery across their fleet with orange to the front of the vehicle and blue to the rear, separated by a broad white diagonal stripe.

[26] During 2021 Leicester City Council successfully applied for £19 million of funding from the Government's ZEBRA scheme with Centrebus operating five Yutong E12 electric buses on the University Hospitals of Leicester Hospital Hopper service, Centrebus gained a further six Yutong E10 buses during late 2022 for the 40 Orbital.

Routes operated by Centrebus include the Rutland Flyer, Leicester Orbital, Hop!, and the 747 Uppingham–Leicester.

Route 314 goes via Codicote and Langley (with the twice a day extension to The Priory School) whilst the 315 goes via Whitewell and Kimpton.