On 17 November 1961, the building became the headquarters for the Centro Español de Ponce, a prominent civic organization working for the preservation of Spanish heritage in the city.

The club’s first directing board included such prominent Ponce residents as Bernardo Valdecilla, Pedro Juan Bonnin, Manuel Gandara, Antonio Vicens, Francisco Font, and Bartolome Melia.

[6] One of the best documented events accomplished by the Centro Español club was the transfer of the remains of Don Rafael Martínez Illescas, a Spanish army commander who had died in the Spanish–American War during the Puerto Rico Campaign, from a Ponce cemetery to his hometown in Cartagena, Spain, on 20 May 1915.

[7] In 1935, the Centro Español de Ponce club hosted Argentina’s king of Tango, Carlos Gardel.

[10] Some time after 1970[11] the building became the Ponce regional office for the Fondo del Seguro del Estado (FSE), the government of Puerto Rico’s pension and health plan agency, until FSE opened new offices on Avenida Santiago de los Caballeros in 1985.