In 2019, Centrus began work under a contract with the U.S. Department of Energy to build a cascade of 16 centrifuges in Piketon, Ohio to demonstrate production of High-Assay, Low-Enriched Uranium, or HALEU.

The United States Nuclear Regulatory Commission assumed regulatory authority over the Portsmouth facility in March 1997 and on June 5, 1998, the agency made an investigation into alleged "failure to control components with uranium deposits, inadequate maintenance, testing and operation of safety valves on equipment, and exceeding the possession limit for uranium enriched greater than 20 percent.

Before its downsizing and final cessation of uranium enrichment on May 31, 2013, the Paducah Gaseous Diffusion Plant consumed about 3,000 megawatts of electricity at peak operation.

[5] On December 16, 2013, USEC announced that it had reached an agreement with a majority of its debt holders to file a prearranged and voluntary Chapter 11 bankruptcy restructuring in the first quarter of 2014.

[14] In October 2015, the U.S. Department of Energy issued a report to Congress which evaluated options to resume U.S.-technology enrichment operations to meet U.S. national security mission needs.