Marsciano borders the following municipalities: Collazzone, Deruta, Fratta Todina, Perugia, Piegaro, San Venanzo, Todi.

The main church in the center of town is the neo-gothic style San Giovanni Battista.

The facade of the 19th century Teatro Concordia serves as a portal to a modern cinema theater.

The municipality is watered by the little Nestore River, a tributary of the Tiber.

Marsciano's eastern border with neighboring Collazzone is marked by the River Tiber itself.