He worked at Santa Maria presso San Celso and to part of the renovation of the Sforza Castle; he collaborated in the painting decoration of Milan Cathedral (Duomo), in the Sala dei Deputati, which was demolished in the 19th century.
Giorgio Vasari wrote in Bramante's vita: Determined to see at least one notable thing, he proceeded to Milan to visit the Duomo, where there happened to be one Cesare Cesariano, reputed a good geometer and architect, who had written a commentary on Vitruvius.
Enraged at not having received the reward which he had expected, Cesare refused to work any more, and, becoming eccentric, he died more like a beast than a man.In 1528 Cesariano was appointed as ducal engineer by the Spanish governor of Milan.
Cesariano is chiefly remembered as the first translator of Vitruvius' treatise De architectura into a modern language (Italian), with his added commentary.
The impenetrable Latin and the lack of illustrations gave freedom to the Renaissance designers, who were able to interpret antique architecture in their own image, all' antica.