Chamberlain is a city in Brule County, South Dakota, United States.

It is located on the east bank of the Missouri River, at the dammed section of the Lake Francis Case, close to where it is crossed by Interstate 90.

[7] Chamberlain is home to the South Dakota Hall of Fame, and the 50-foot tall Dignity statue is nearby.

Chamberlain was named after Selah Chamberlain, a railroad director of the Chicago, Milwaukee and St. Paul Railway, as it was established by European Americans in relation to the construction of the railroad.

There were 1,142 housing units at an average density of 172.0 per square mile (66.4/km2).

36.9% of all households were made up of individuals, and 15% had someone living alone who was 65 years of age or older.

36.2% of all households were made up of individuals, and 15.2% had someone living alone who was 65 years of age or older.