Named after Society of Mary founder William Joseph Chaminade, Chaminade College Preparatory consists of a middle school (encompassing grades 6–8) located in Chatsworth and a high school (encompassing grades 9–12) located in West Hills.

Originally called Chaminade High School for Boys, Chaminade College Preparatory was founded in 1952 on the former site of the Pacific Military Academy in West Los Angeles by members of the Marianist Province of the Pacific, who were seeking to expand their educational mission into Southern California.

The high school moved to its current location in West Hills (then part of Canoga Park) in 1961 after the brick buildings of the original campus were deemed unsound.

[10] In 2015, the girls' basketball team won the CIF Southern Section Open Division championship.

[12] In 2014, a column by Los Angeles Times reporter Eric Sondheimer identified Chaminade as one of a number of elite prep schools contributing to the professionalization of high-school sports.

"[13] In 2013, five Catholic orders released the confidential personnel files of a dozen priests and nuns accused of sexually abusing minors throughout previous decades.

The files revealed that priest Joseph DiPeri was accused of molesting a student at Chaminade High School in 1977–78.

A letter from a Los Angeles police detective in the file noted that, "There was no mandatory reporting at the time of the alleged incident."