Between 2011 and 2020, Parsons played in the NBA for the Rockets, the Dallas Mavericks, the Memphis Grizzlies, and the Atlanta Hawks before injuries caused by a drunk driver forced him into retirement.

[2] As a senior, Parsons was a first-team all-state selection, and was recognized as the most valuable player of the state championship game after scoring thirty points and grabbing ten rebounds.

Parsons commented that playing for four years under Donovan gave him an advantage over other players who left the team early.

[4] On January 3, 2010, Parsons hit a seventy-five-foot shot with no time left on the clock in overtime to give the Gators a one-point victory over North Carolina State.

[6] On March 8, 2011, he was named the 2011 SEC Player of the Year, becoming the first Florida Gator to win that honor.

[14] In the Rockets' season finale on April 22, 2012, Parsons scored a season-high 23 points against the Miami Heat.

[27] On March 8, 2015, Parsons returned to action against the Los Angeles Lakers after a seven-game absence with a sprained left ankle.

[33] On March 25, he underwent successful surgery to address the torn meniscus in his right knee, ruling him out for the rest of the season.

On November 6, he made his debut for the Grizzlies against the Portland Trail Blazers, but in 22 minutes as a starter, he missed all eight of his field goals attempts.

[37] He appeared in six games for the Grizzlies before missing the next 17 with a bone bruise on his left knee, making his return to the line-up on December 21 against the Detroit Pistons.

[41] Chandler had an extended stint on the sidelines between late December and mid-February due to right knee soreness.

[44] Parsons earned a starting spot for the 2018–19 season out of training camp,[45] but only played in the first three games before being sidelined with right knee soreness.

Parsons had been willing to play in the G League but wanted a clearer plan and a timetable in place that would return him to the Grizzlies' active roster.

[45] As a result, on January 6, he left the team indefinitely as the two sides worked to structure a resolution on his future.

[61] Parsons also signed sponsorship deals with the Chinese telecommunications company ZTE and the California-based apparel manufacturer Stance.