That same season, along with 6 ft 11 in (2.11 m) teammate Ángel García and future Carolina Panther Kawann Short,[3] Moore led his team to the 2007 Indiana High School Athletic Association 4A State Championship, scoring 28 points against Indianapolis North Central High School, which starred 2007 Indiana Mr. Basketball and current NBA player, Eric Gordon.

[14][15] Moore, Hummel and Martin were teammates in the Amateur Athletic Union (AAU) basketball program and were united with Johnson on the Indiana State All-Star squad.

He became roommates with fellow freshman teammate, Robbie Hummel, and shared a common bathroom with JaJuan Johnson and Scott Martin.

[17] He led the "baby boilers" in scoring with 12.9 points a game, becoming the first true freshman in Boilermaker history to lead in that category.

[20][23] Moore helped lead Purdue to a 2nd straight NCAA tournament appearance, losing to a senior-led Xavier team in the Second Round after defeating the Baylor Bears, and led the Boilers to a 25–9 overall record.

[19] Moore finished his sophomore season for the 2008–09 Boilermakers as the leading scorer for the team again and ranked second in assists as well as third in rebounds.

[23] The 37 games in which he appeared in is a season-school record, which he shares with JaJuan Johnson, Marcus Green and Keaton Grant.

[23] To start the 2009–10 season, Moore was named a preseason candidate for the John R. Wooden Award along with teammate, Robbie Hummel.

[36] With a 22-point performance against Tennessee and being named the 2009 Paradise Jam tournament MVP,[37] he became the 43rd Boilermaker to score his 1,000th career point.

[42][43] Leading Purdue in scoring with 16.5 points a game and shooting beyond the arc at 34.3 percent, he was also second on the team with 2.7 assists per outing behind Lewis Jackson's 3.5 mark.

Moore was named a First Team All-Big Ten selection by both the coaches and the media at the conclusion of the regular season.

[47] Moore led Purdue to a 4 seed in the NCAA tournament, culminating with a consecutive Sweet Sixteen after beating Siena and Texas A&M.

Eventually losing to Duke for the second time in his career, he led Purdue to a 29–6 record, which tied for the most season wins in school history.

He concluded the season sixth in the Big Ten Conference in scoring (teammates Hummel and Johnson finished seventh and eighth) and ninth in steals.

[49][50] After being named First Team All-Big Ten in his junior season, Moore decided to enter the 2010 NBA draft along with teammate JaJuan Johnson.

[56] Moore had another 31 point performance New Year's Eve against Northwestern, which included a career-high of 7 made three-point field goals in a game.

He recorded season highs of 7 assists against Alcorn State on November 17, 9 rebounds (4 times), and 4 steals against Austin Peay.

[64] Moore was also a National Association of Basketball Coaches (NABC) Division I District 7 All‐District second team choice.

[66] Moore was selected by the United States Basketball Writers Association to its 2010–11 Men's All-District Team.

[68] Moore finished his senior year averaging career highs of 18 points (2nd on team), 5.1 rebounds (2nd), 3.2 assists (2nd), and .5 blocks.

[78][79] In the subsequent weeks with Keyon Dooling and Sasha Pavlović injured he often received a significant amount of playing time.

[90] On December 28, Moore suffered an elbow sprain when he and Cartier Martin landed on his arm during a loose ball scramble against the Washington Wizards.

[95] When Nelson incurred a bruised left forearm, Moore returned to the starting lineup on February 2 against the Milwaukee Bucks.

[101] On February 21, the Magic traded away Redick,[102] and Nelson was diagnosed with a strained left knee patella tendon.

[114] With injuries sidelining Derrick Rose, Jimmy Butler and Taj Gibson on March 5, 2015, Moore scored a career-high 19 points and hit the game winning three-point shot with 2.1 seconds remaining to help the Bulls defeat the Oklahoma City Thunder 108–105.

[117] On February 21 against the Los Angeles Lakers, Moore scored 24 points again on the night that Kobe Bryant made his farewell visit to the United Center.

[119] Moore began the season with a 10-point performance as a starter in his debut for the Pelicans on October 26, 2016, against the Denver Nuggets, but missed a game-tying three point shot attempt with 24 seconds left.

Moore eventually received a start on February 8 with Chris Paul out due to a sore right hamstring, scoring a season-high 17 points with 4 assists in 39:41 minutes of action for a 119–113 win over the Cleveland Cavaliers.

On September 8, 2021, Moore signed with the Orlando Magic, returning to the franchise for his second stint with the team.

[133] His business portfolio also includes ownership of two McAlister's Deli restaurants, an executive transportation company in Orlando, and real estate in Indiana, New Orleans and Texas.