Built in the 1930s, the chapel pews were hewn from narra and carried the Signum Fidei Star, the sign of faith and the symbol of the De La Salle Brothers.

On February 12, 1945, during the liberation of Manila at the peak of World War II, retreating Japanese troops massacred at least 60[2] civilians inside the chapel as they sought refuge from the ongoing battle, believing that the building's thick walls would protect them from anything but a direct hit.

[3] On December 2, 2014, the 75th year jubilee of the Chapel of the Most Blessed Sacrament was celebrated, with a Mass presided by a De La Salle University alumnus, Rev.

[4] Even before De La Salle College moved to its present location at Taft Avenue in Malate, Manila, the school already had its own chapel.

The then De La Salle College Director-Brother Egbert Xavier FSC was about two days earlier forcibly taken by a group of Japanese soldiers and was never seen again.

[7][8][9] On December 16, 1946, a written permission was received from Archbishop Michael J. O'Doherty to have the reconciliation ceremony and the re-dedication of the Chapel to the Most Blessed Sacrament.

The original panes in the glass doors were of pre-war vintage, imported, and had, over the years, been patched with varicolored substitutes.