[10] He was appointed as the Secretary of Education of the Philippines on June 30, 2010,[11][12] becoming the second De La Salle brother to hold the post—the other was Gonzalez who was in office from 1998 to 2001.

[14][15] The Alliance of Concerned Teachers (ACT) have expressed skepticism over Luistro's stand on sex education citing his religious background.

Roman Catholic groups have criticized it for allegedly not covering the emotional, psychological and spiritual dimensions of sexuality.

[18][19] Numerous parties had opposed the plan including Ateneo de Manila University President Bienvenido Nebres and progressive groups of students, teachers and parents.

He pursued his undergraduate studies at De La Salle University in Manila under a scholarship, and was conferred Bachelor of Arts in Philosophy and Letters in March 1981.

"[9] In 1981 he entered into a program in Ateneo de Manila University, and was awarded a Certificate in Formation Institute for Religious Educators in 1985.

[3] He was made Doctor of Humane Letters, honoris causa, by La Salle University in Philadelphia, Pennsylvania, United States on May 9, 2004.

In which structure, DLSU served as the flagship while other De La Salle institutions specialized in fields like agriculture, alternative education and medicine.

He also delivered a eulogy (named Cory, the Heart of a Saint) during the wake of former President Corazon Aquino, and said "our closeness with her was really borne out of that period [Hello Garci scandal], none of her children went to La Salle.

[6][13] Aquino gave Luistro two years to address problems, including insufficient books, classrooms and teachers.

[17] Likewise, former Roman Catholic Archbishop of Lingayen-Dagupan Oscar V. Cruz criticized Luistro for his alleged lack of comment regarding the Reproductive Health Bill, which proposes to integrate sex education in public schools.

The program seeks to add two years to the current 10-year basic education curriculum, and make graduates more competitive.

[27] Numerous parties have opposed the plan including Ateneo de Manila University President Bienvenido Nebres and progressive groups of students, teachers and parents.

[20] A spokesperson of No To K–12 Alliance said: The fact that it will aggravate the financial burden of parents and that the Aquino proposed education budget cannot resolve the shortages even under the current 10-year system clearly explains the program's foolishness.

Adding two years will just add salt to the already rotting wound of basic education.Luistro signed on behalf of the Deped the national policy framework for Indigenous peoples education in 2011.

[29][30] The framework directs DepEd offices and units to ensure that textbooks and other learning materials are free from discriminatory and erroneous content that misrepresent the history and culture of Indigenous peoples.