Chapin High School competes in the South Carolina High School League in Class AAAAA – Region V. Chapin has competitive teams for cheerleading, football, baseball, basketball, softball, tennis, soccer, volleyball, golf, wrestling, swimming, lacrosse, track, and cross country.

[3] The Chapin High School “Pride of the Midlands” Marching Band has won state championships in 1975 (1A), 1985 (2A), 2012 (3A), 2014 (3A), 2015 (3A), and 2017 (3A).

[19] In 2023, the school board of Chapin High School received complaints against a teacher who assigned Ta-Nehisi Coates's book Between the World and Me in an Advanced Placement English class.

The book was assigned to help present the perspective of being "Black in America".

Ta-Nehisi Coates himself attended the school board meeting in which the teacher was reprimanded.