Born in Boston, Massachusetts, Wyzanski attended Phillips Exeter Academy, and received an Artium Baccalaureus degree from Harvard University in 1927.

He was a law clerk for Judge Augustus Noble Hand of the United States Court of Appeals for the Second Circuit from 1930 to 1931.

[citation needed] Wyzanski published the book Whereas--A Judge's Premises : Essays in Judgment, Ethics, and the Law with Little, Brown (1965).

Among other prominent correspondents were: Bailey Aldrich; Hugo L. Black; Kingman Brewster; Ralph Bunche; McGeorge Bundy; Arthur J. Goldberg; Edward M. Kennedy; Frances Perkins; Nathan M. Pusey; Stanley Forman Reed; Franklin Delano Roosevelt; Leverett Saltonstall; Adlai Stevenson; Earl Warren; and Alfred North Whitehead.

The seventeen printed items (1936–1940), some bound, some unbound, are from Judge Wyzanski's Washington years, particularly from his service as special assistant to the Attorney General of the United States, and on the staff of the Solicitor General of the United States The group of papers given to the Harvard Law School Library in 1984 relate to the origin of the National Labor Relations Act of 1935; all materials are photocopies.

1920-1986 consisting of 34 cartons is now held by the Massachusetts Historical Society in Boston, MA and is currently closed to researchers pending processing.

According to the MHS catalog record, the collection is described as "Papers of Judge Charles E. Wyzanski consist of both personal and professional materials.

Personal papers include correspondence with family and friends, autobiographical writings, speeches and addresses, articles, and lectures; items pertaining to Harvard University, various foundations, and clubs to which he belonged; and some materials from his school days at Phillips Exeter Academy.

"[4] Judge Wyzanski was interviewed for the Oral History Project of Columbia University by Harlan Phillips in 1954, entitled "The Reminiscences of Charles E.