He early gave his attention to auscultation, which was first introduced into Baltimore by his brother-in-law.

In 1855 and 1856, he took a conspicuous part in the Baltimore Pathological Society.

In 1856, he was selected to fill the chair of materia medica in the Maryland College of Pharmacy, which he had aided in organizing.

In 1858, after his return from an extended European tour, he accepted the professorship of materia medica and therapeutics in the University of Maryland School of Medicine, and at the same time took charge of the medical department of the Baltimore Infirmary as visiting physician.

He published Renal Diseases (1850), and contributed papers to the Journal of Medical Science and other scientific periodicals.