Charles Lewis Mitchell (November 10, 1829 – April 13, 1912) was a printer, officer in the Union Army during the American Civil War, and state legislator in Massachusetts.

During the American Civil War he served in the 55th Massachusetts Colored Volunteer Infantry and was wounded at the Battle of Honey Hill in South Carolina, resulting in the loss of one foot.

Taking his seat in January 1867, he and Edward G. Walker became the first African Americans to hold legislative offices in Massachusetts.

[8] At William Lloyd Garrison's funeral in Boston, in May 1879, Mitchell was one of eight pallbearers, along with Wendell Phillips and Lewis Hayden.

Nellie Brown Mitchell also sang at the funeral, as part of a quartet of African American singers.