Charles Nohuoma Rotimi (born 1957) is the Scientific Director of the National Human Genome Research Institute (NHGRI).

Rotimi was instrumental in the launch of the Human Heredity and Health in Africa (H3Africa) with the NIH and the Wellcome Trust.

[2] Rotimi completed his PhD and then spent a year as a postdoc at the Loma Linda University in California.

[5][6] He was appointed as an epidemiologist at Loyola University Chicago, where he worked on cardiovascular disease and obesity in people in the African diaspora.

[2] Together with his colleague Richard Cooper, Rotimi recruited 10,000 people to study the prevalence of hypertension in populations of West African descent.

[5] He found that hypertension and diabetes rates are significantly higher in African-American populations in Chicago than they are in rural Africa.

[5] Rotimi moved to Howard University in 1990, where he worked with Georgia M. Dunston at the National Human Genome Center.

[2] The study established that 97 % of people have mixed ancestry, emphasising the problems with labels such as hispanic, black and white.

[11] He began to work with Kári Stefánsson in 2007, studying the diabetes risk variant TCF7L2 in West African populations.

[12] He demonstrated that both TCF7L2 and its genetic variant HapA increase the risk of diabetes due to their function in energy metabolism.