Charles Towne Square was an indoor shopping mall located in North Charleston, South Carolina opened in 1976 by developer Melvin Simon & Associates.

The mall's tenants included original anchors Montgomery Ward, JCPenney and Edward's, a local department store which would later be sold to Kuhn's-Big K and renamed "Big K-Edwards."

Other special guests included World War II soldier Mark Clark, football player Rosey Grier, and Claude Akins.

Changing economic conditions spurred by the closure of the nearby Charleston Naval Base prompted anchor JCPenney to relocate to the larger Northwoods Mall in the early 1990s followed by the exit of Service Merchandise.

The mall was demolished and an 18-screen Regal Cinemas was added along with a Courtyard by Marriott hotel; however, plans for the big box retailers and other shops never materialized.