The second largest is CAMC General Hospital, located downtown, which focuses on neurology, orthopedics, trauma, and rehabilitation care.

CAMC's fourth campus is the CAMC-Teays Valley Hospital, located in Putnam County to the west of Charleston, and serves that suburban area.

The fifth campus, added in 2023 as CAMC-Greenbrier Valley Medical Center, is located in Greenbrier County towards the southeastern corner of West Virginia.

CAMC provides the most uncompensated care in the state of West Virginia, with a total benefit to the community over $115 million per year.

[13] The HealthGrades website contains the latest quality data for Charleston Area Medical Center, as of 2015.