In an ensemble cast, Cameron Diaz, Drew Barrymore and Lucy Liu reprise their roles as the three women working for the Townsend Agency.
Crispin Glover, Matt LeBlanc and Luke Wilson also reprise their roles from the first film in addition to Bill Murray appearing through archival footage with Bernie Mac, Justin Theroux, Robert Patrick and Demi Moore joining the cast.
Marshal Ray Carter in Mongolia, the Angels (Natalie Cook, Dylan Sanders, and Alex Munday) and Jimmy Bosley (John Bosley's adoptive brother) are sent to recover titanium rings stolen from the United States Department of Justice that can display the people listed in the witness protection program.
During the Coal Bowl motorcycle race, Emmers targets another witness named Max Petroni, and the Angels try to intervene.
Inside Emmers' pocket, the Angels discover the photos of Caulfield, Max, and, surprisingly, Dylan, under her birth name, Helen Zaas.
Dylan reveals that she is a protected witness after sending her former boyfriend, Irish mob leader Seamus O'Grady to prison.
Natalie and Alex deduce that Carter is the one who let O'Grady out of prison after seeing him return Bosley's keys without any pain, despite claiming to have broken his ribs recently.
Though Dylan arrives to back the group, the Angels are shot by Madison, who takes the rings, though they survived via Kevlar vests.
The Angels realize that Madison is going to sell the rings to the O'Grady Crime Family, the Antonioni Mafia, the Tanaka Yakuza, and the Diablo Cartel at the Hollywood Walk of Fame, where Jason's film premiere is about to commence.
The Angels fight Madison all the way to an abandoned theatre, where they kick her into a chamber filled with gas and she fires her gun, inadvertently blowing herself up.
The site's critical consensus reads: "Eye candy for those who don't require a movie to have a plot or for it to make sense".
[12] Ebert explained: "I realized I did not hate or despise the movie, and [...] I decided that I sort of liked it because of the high spirits of the women involved".
[11] Amy Dawes of Variety magazine wrote: "Bigger, sleeker and better than the first, sequel Charlie's Angels: Full Throttle is a joyride of a movie that takes the winning elements of the year 2000 hit to the next level".
[15] Demi Moore was nominated for the MTV Movie Award for Best Villain, but lost against co-star Lucy Liu for her role as O-Ren Ishii in Quentin Tarantino's Kill Bill: Volume 1.
[16] Charlie's Angels: Full Throttle was released on both VHS and DVD in widescreen and full-screen formats on October 21, 2003.