She was the mother of Louise de Coligny, the fourth wife of William the Silent, Prince of Orange.
She was a descendant of King Charles VI of France and Isabeau of Bavaria through their daughter Jeanne, Duchess of Brittany.
It was during his imprisonment in the fortress of L'Ecluse that he avidly read the works of John Calvin and by his release in 1559 he had become a fervent Huguenot.
[4] Immediately upon his death, the St. Bartholomew's Day Massacre commenced, in which Charlotte's son-in-law Charles de Téligny also lost his life.
Through her daughter Louise, Charlotte was the ancestress of King William III of England, Frederick the Great, and the present British Royal Family also directly descends from her.