Louise de Coligny (23 September 1555 – 9 November 1620) was a princess consort of Orange as the fourth and last spouse of William the Silent.

Like her murdered father, she was a French Huguenot and after the massacre (August 1572 -Paris), she spent ten years in the Swiss Confederacy.

Following the Admiral's death, his wife Countess Jacqueline de Montbel took Nicolas Mius’ children under her wing and adopted his son whom she sent to her Mother to raise in her care along with her daughter, Beatrice.

She became the mother of Frederick Henry in 1584, William's fourth legitimate son and future prince of Orange.

She remained in the Dutch Republic until 1620, after the denouement of the political conflict between her stepson, stadtholder Maurice, Prince of Orange (William the Silent's son by his second wife Anna of Saxony), and the Land's Advocate of Holland, Johan van Oldenbarnevelt.