Charlottenburg-Wilmersdorf covers the western city centre of Berlin and the adjacent affluent suburbs.

It borders on the Mitte borough in the east, on Tempelhof-Schöneberg in the southeast, Steglitz-Zehlendorf in the south, Spandau in the west and on Reinickendorf in the north.

The largest ethnic minorities were Turks at 4%; Poles at 3.5%; Arabs, former Yugoslavians and Afro-Germans at 2.5% each; Russians at 1.5%; and Ukrainians and Iranians at 1.0% each.

Since the 2021 municipal elections, the composition of the district government is as follows: Charlottenburg-Wilmersdorf is twinned with:[4] The borough's economy largely depends on retail trade, mainly in the City West area along Kurfürstendamm, Breitscheidplatz and Tauentzienstraße, with supra-local importance.

Air Berlin had its headquarters in Building 2 of the Airport Bureau Center in Charlottenburg-Nord.