It is served by Amtrak Pacific Surfliner inter-city rail service, Metrolink Ventura County Line commuter rail service, and the Metro G Line of the Los Angeles Metro Busway bus rapid transit.

The Southern Pacific Railroad (SP) opened a 22-mile (35 km) branch line from Burbank to Chatsworth in 1893.

[6][7] The 1893-built station was a typical style: a two-story wooden depot with a longer one-story freight house.

[6][7] An infill station opened in Chatsworth on the short-lived CalTrain line on December 29, 1982, only to close when service ended on March 2, 1983.

[10] The stop was located just east of DeSoto Avenue, 1.2 miles (1.9 km) southeast of the former SP station site.

[17] As of January 19, 2025[update], the following connections are available:[18] Media related to Chatsworth station at Wikimedia Commons