Cheska Garcia was born in Makati, Philippines to Francisco Pablo Pellicer Garcia, a Spanish mestizo, and Maria Celeste Dahlia Villalobos Velasco, an Ilongga from Roxas City, Capiz.

The actresses Sharmaine Arnaiz and Bunny Paras, who are sisters, are her maternal cousins.

[citation needed] In 1992, Garcia began her television career, along with her brother Patrick; both appeared as cast members for Ang TV until 1996.

In 2015, Garcia hosted Mommy Hacks, a parenting lifestyle show on CNN Philippines, with Rica Peralejo-Bonifacio.

[3] On April 22, 2024, Garcia mourned the passing of her mother, Maria Celeste Dahlia Villalobos Velasco.