[3] The drainage basins in Cheyenne County include Bellyache, Big Timber, East and Middle Fork Big Spring, Eureka, Goose, Ladder, Little Spring, Pass, Rock, Sand, Turtle, White Woman, Wild Horse and Willow Creeks, as well as the Smoky Hill River.

The creeks in the northern and eastern part of the county drain to the Republican or Smoky Hill Rivers; those in the central and southeastern part of the county drain ultimately to the Arkansas River.

All of the creeks in Cheyenne County are generally dry with some flow when drawing snowmelt or rainfall.

In the 27 presidential elections since 1920, the Democratic presidential candidates have carried the county only five times, none have broken 60% of the vote, and only Lyndon Johnson in 1964, and Franklin Delano Roosevelt in 1932 won the county by a double-digit margin.

By contrast, the Republican nominees have carried the county 22 times, including the last twelve in a row, with all except Wendell Willkie in 1940 winning by at least a double-digit margin.

The four most recent GOP presidential candidates George W. Bush, John McCain, Mitt Romney, and Donald Trump all carried Cheyenne county with over 80% of the vote.