Tilesi moved to the United States when she was eighteen, to attend Loyola Marymount University in Los Angeles, California, where, in 1995 she graduated cum laude in liberal arts.
The CD, a collection of love poems by the poet Pablo Neruda read by famous Italian artists, eventually enjoyed great commercial success and critical acclaim.
[1][2] She was invited to participate as a Cultural Leader and official speaker to the World Economic Forum Annual Meeting, held in Davos, Switzerland.
Tilesi presented her inspirational speech at the Betazone "The Female Icon", on the disruption of the paradigm and how women's narratives can change, joining other industry leaders and cultural figures like WDIT board member Aifaa Al-Mansour, Marin Alsop, Sir David Attenborough, Bono, David Blaine, Karan Johar, Michelle Yeoh, and more in an effort to advance a dialogue discussing how inclusivity and sustainability can be the pillars of change.
Tilesi's first feature film, All the Invisible Children, was produced for UNICEF and the World Food Program, with a release in 120 countries and the co-direction of Ridley Scott, John Woo and Spike Lee, among others.
[13] The film consists of seven segments directed by a diverse and internationally renowned group of women filmmakers, including Margherita Buy, Cara Delevingne, Jacqueline Fernandez, Marcia Gay Harden, Jennifer Hudson, Eva Longoria, Pauletta Washington, and Anne Watanabe.
[16] On May 9, 2023, Tilesi received the Pegaso Delle Donne Award from Eugenio Giani, President of the Region of Toscana, on the occasion of the special screening of Tell It Like A Woman.
[20] The West Coast episode was premiered two days later at Mr. Brainwash Art Museum in Los Angeles and included the talent Giada De Laurentiis, Raffaella Camera, Federica Raia, and Gabriella Pession.