Chihr-Burzen, also known as Simah-i Burzin, was an Iranian nobleman from the House of Karen, who served as the Sasanian spahbed of Khorasan.

Chihr-Burzen was the son of the powerful Sasanian noble Sukhra, and had 8 other brothers, which included the prominent nobleman Bozorgmehr.

Chihr-Burzen is first mentioned during the reign of Khosrau I, as one of the elites and most prominent men of the Empire.

He, along with two other powerful magnates named Izadgushasp and Bahram-i Mah Adhar, were asked by Khosrau I to choose his successor.

In 579, Khosrau was succeeded by his son Hormizd IV, who removed Chihr-Burzen as the spahbed of Khorasan and replaced him with his brother Bozorgmehr.