Izadgushasp (also spelled Yazdgushnasp), known in Byzantine sources as Isdigousnas Zikh, was an Iranian nobleman from the House of Mihran, who served as one of Khosrow I's viziers (wuzurg framadar).

Procopius describes them as: "both holding most important offices ... and at the same time reckoned to be the basest of all Persians, having a great reputation for their cleverness and evil ways.

During the peace negotiations to end the war, Izadgushasp was the spokesman of the Sasanians, and made a treaty with the Byzantines in which they paid a great tribute of gold.

However, this plan was prevented by a former of adviser of Belisarius named George, who demanded that if Izadgushasp should enter the city he should have only twenty members of his crew with him.

In 579, Khosrow was succeeded by his son Hormizd IV, who later ordered the death of 13,600 nobles and religious members,[6] including Izadgushasp, who was first imprisoned and then executed.