They raised money from local churches, and the hospital opened at Levi Cory House at Mountain Avenue and New Providence Road on July 15, 1892.

In 1988, it founded its Pediatric Long Term Care Unit for 25 children, and also opened the hospital's Outpatient Center in Fanwood.

By 2015, other programs included treating "complex physical disabilities like brain and spinal cord injuries, to developmental and behavioral issues like autism and mental health.

[7] In 2012, the hospital released research showing that six underserved communities in New Jersey cities had higher rates of autism.

The test involved the screening of 1,000 children from Newark, Plainfield, Elizabeth, Trenton, New Brunswick and Bridgeton, and was funded by the New Jersey Governor's Council for Medical Research and Treatment of Autism.

[9] Around 2011, the hospital began focusing a lot on research into rehabilitation in five big areas: autism, mobility, cognition, brain injury, and chronic illness.

These were in Mountainside, Fanwood, two in New Brunswick, Roselle Park, two in Toms River, Newark, Egg Harbor Township, Hamilton, Clifton, Bayonne, and Warren.