Attached to the medical center is the Children's Hospital of New Jersey, which treats infants and young people up to age 21.

The hospital was run under auspices of the Newark Jewish Community and its suburban successors from its inception in 1900–1901 until its purchase by RWJBarnabas Health in 1996.

[4][5] In 2011, the Newark Beth Israel Medical Center was ranked among the top 50 hospitals in the United States for specialty care in cardiology and heart surgery.

[8] In 2019 regulators found incidents in which the hospital put patients in "immediate jeopardy" following unsuccessful surgeries, and did not carry out its own recommendations, leading to mistakes on subsequent operations.

[9] Regulators also discovered instances hospital staff who failed to obtain informed consent or follow patients' and family members' "do not resuscitate" orders.