In 2006, Lisa-ann Gershwin noted that the South American neotype's cnidome was differing from the United States species.

When this happened on the Texas Gulf coast in 1955 and 1956, it coincided with drought conditions and an associated high salinity level in the area.

After gales large quantities were washed up on the beach, and after heavy rains, many dead jellyfish were found floating on the surface.

[5] The long tentacles of Chiropsalmus quadrumanus are armed with nematocysts, the purpose of which is to capture prey such as small fish and to deter predators.

[6][7] Of forty-nine people stung by jellyfish off the coast of Brazil over a five-year period, twenty were by identifiable species.

Sixteen of these were identified as being caused by Chiropsalmus quadrumanus and four by the Portuguese man o' war (Physalia physalis).