Chlorosulfolipid

In addition to being integral components of algal membranes, chlorosulfolipids are also known to inhibit protein kinases.

[2] The lipid malhamensilipin A, isolated by the groups of Slate and Gerwick in 1994, displayed both antimicrobial activity as well as an inhibition of the pp60 protein tyrosine kinase.

Elovson demonstrated that the C-14 secondary hydroxyl group of molecule 3 was incorporated by oxidation of the fatty acid with molecular oxygen, as opposed to alkene hydration with water.

The next step involves the enzyme-mediated transfer of the sulfate group from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to the diol to form molecule 4.

[4] Walsh has demonstrated that the halogenation of unactivated methyl groups can be catalyzed by a newly discovered class of α-ketoglutarate-dependent non-heme iron halogenases, suggesting a similar enzyme family could play a role in chlorosulfolipid chlorination.