He is best remembered for hitting a series-ending walk-off home run in Game 4 of the 2005 National League Division Series.

In 2001, his junior year, Burke moved to shortstop and helped the Volunteers make an appearance in the College World Series by hitting .435 with 20 home runs and 49 stolen bases, being named to the CWS all-tournament team.

In 2003, Burke was named Round Rock's Team MVP and a Texas League All-Star after batting .301 with 3 home runs and 41 RBI.

He played on the USA Baseball Olympic qualifying team and was named the starting second baseman for the All-Star Futures Game.

Burke hit the series-winning walk-off home run off Joey Devine of the Atlanta Braves' that ended Game 4 of the 2005 National League Division Series (NLDS).

On December 14, 2007, he was traded to the Arizona Diamondbacks along with Chad Qualls and Juan Gutiérrez for José Valverde.

[3] After not making the team in Spring Training, Burke was traded to the Seattle Mariners for cash considerations.