He played college football for the Missouri Tigers, and was selected by the Chiefs in the second round of the 2021 NFL draft.

The Chiefs used a 2nd round selection they previously acquired along with Orlando Brown Jr. in a trade that sent the 31st overall pick in the 2021 NFL draft (Odafe Oweh) to the Baltimore Ravens.

[20] During the 2022 season, Bolton recorded two sacks, 180 total tackles (108 solo), two interceptions, three passes defended, and one forced fumble.

[21] He finished second in the NFL in combined and solo tackles in the 2022 season,[22] helping the Chiefs reach Super Bowl LVII.

He then played a key role in their 38–35 victory over the Philadelphia Eagles,[23] leading both teams with nine total tackles, and returning a fumble by Jalen Hurts 36 yards for a touchdown.

This would, in essence, end the game and send the Kansas City Chiefs to the playoffs, marking their 10th straight appearance in the postseason.