He played college football for the Michigan Wolverines and was selected by the New England Patriots in the second round of the 2020 NFL draft.

As a freshman in 2016, Uche tore his meniscus, caught a "bad virus" and appeared in only four games.

"[2] Uche met with defensive coordinator Don Brown to express his frustration and ask for more playing time in 2018.

"[2] Michigan head coach Jim Harbaugh described Uche as "highly determined and motivated.

"[2] At the end of the 2018 season, he received honorable mention from both the coaches and media on the 2018 All-Big Ten Conference football team.

It was announced that Uche would forgo his final year of eligibility and declare for the 2020 NFL draft.

[9] Uche was the second (of three) Michigan linebackers the Patriots drafted in consecutive years, following Chase Winovich and preceding Cameron McGrone.

[11] In Week 10 against the Baltimore Ravens on Sunday Night Football, Uche recorded his first career sack on Lamar Jackson during the 23–17 win.