Christine Juliane of Baden-Durlach (12 September 1678 – 10 July 1707), was a German noblewoman of the House of Zähringen and by marriage Duchess of Saxe-Eisenach.

Born at Karlsburg Castle in Karlsruhe, Durlach,[1] she was the oldest of the four children of Prince Charles Gustav of Baden-Durlach (younger brother of Frederick VII, Margrave of Baden-Durlach) and his wife, Princess Anna Sophia of Brunswick-Wolfenbüttel.

The only surviving child of her parents (her three younger brothers all died in infancy), in Wolfenbüttel on 27 February 1697 she married Prince John William of Saxe-Eisenach (younger brother of Duke John George II) as his second wife.

One year later (10 November 1698), her husband inherited the Duchy of Saxe-Eisenach after his brother's death without issue.

During her marriage, Christine Juliane gave birth seven children, of whom only three survived to adulthood: One month after her last childbirth, Christine Juliane died in Eisenach, aged 28.