He started his acting career when he was only two years old in TV commercials, and became known worldwide after his roles as Diego Bustamante in the soap opera Rebelde and Father Ramiro Ventura in the supernatural horror web series Diablero.

[5] Uckermann starred in the hit TV series of mystery and science fiction Kdabra, produced in Latin America by Fox.

On 21 December 2018, he starred in the Mexican television web series Diablero as Father Ramiro Ventura, which was made for and is streaming on Netflix.

They have sold over 20 million albums worldwide, and have toured across Mexico, South America, Serbia, Romania, Slovenia, the United States, and Spain.

[13] Uckermann composed and recorded the track "Sueles Volver", his only solo song, for RBD's fourth Spanish-language studio album, Empezar Desde Cero.

In September 2020, RBD announced that their music would finally be re-released on streaming platforms, accompanied by a virtual reunion show to celebrate.

The show took place on 26 December, with only Uckermann, Anahí, Maite and Christian returning, with Dulce and Alfonso being absent for personal reasons.

In 2017, he announced the release of a new project, an EP called La Revolución de los Ciegos ("The Revolution of the Blind").