The Chulitna River (Dena'ina: Ts'ilutnu) is a 110 km long right tributary of the Susitna River in southern part of interior Alaska.

[2] Chulitna River originates from the confluence of Middle and East Fork Chulitna River in the valley between the Alaska Range and Talkeetna Mountains east of Denali, flows in a southerly direction to Talkeetna, where both it and the Talkeetna River empty into the Susitna River, which flows into Cook Inlet.

The mean discharge near the mouth is 250 m³ / s. The highest monthly discharges of the river, which is mainly fed by glacial meltwater, occur in the months of June to August.

The George Parks Highway from Anchorage to Fairbanks runs parallel to the entire river.

Chulitna River has a subarctic climate (Köppen Dfc).