Saint Mary of the Rose (Italian:Santa Maria della Rosa) is a Renaissance-style, Roman Catholic church located in Chianciano Terme, Province of Siena, Italy.

The present The church was designed by the architect Baldassarre Lanci from Urbino, who had been working for the Grand Dukes of Tuscany since 1557.

The arms of the church join under the square tiburium forming a dome surmounted by a polygonal lantern.

The interior of the dome was painted by the Sienese painter Giovan Battista Marchetti and later decorated with stucco.

The interior contains a fresco attributed to an unknown Sienese painter depicting the Madonna handing a white rose to baby Jesus between St. John the Baptist and St. Bartholomew, protectors of Chianciano, painted between 1370 and 1400.