The Chyhyryn Regiment (Ukrainian: Чигиринський полк) was one of the seventeen territorial-administrative subdivisions of the Hetman State.

The regiment's capital was the city of Chyhyryn, now in the Cherkasy Oblast of central Ukraine.

Following the signing of the Treaty of Zboriv in 1649, it consisted of a total of 19 sotnias and had 3,222 registered Cossacks.

Following the signing of the Treaty of Karlowitz, Polish authority was reinstated on the territory in 1699.

The regiment came under the jurisdiction of Ivan Mazepa in 1704, who reunited both banks under his rule during the Great Northern War, but was dissolved in 1712 when the territory was returned to the Polish–Lithuanian Commonwealth and its population was transferred to Left-Bank Ukraine.