Chymotrypsinogen

Chymotrypsinogen is an inactive precursor (zymogen) of chymotrypsin, a digestive enzyme which breaks proteins down into smaller peptides.

Chymotrypsinogen is a single polypeptide chain consisting of 245 amino acid residues.

[2] Chymotrypsinogen must be inactive until it gets to the digestive tract, in order to prevent damage to the pancreas or any other organs.

One π-chymotrypsin acts on another by breaking a leucine and serine peptide bond.

[4] The yield of α-chymotrypsin can be affected by inhibitors such as hydrocinnate and also by pH, temperature and calcium chloride.