[5] Cinacalcet was approved in the United States in March 2004,[4][7][8] and in the European Union in October 2004.

[4][12] Cinacalcet can also be used to treat severe hypercalcemia in patients with primary hyperparathyroidism who are unable to undergo parathyroidectomy.

Hypocalcemia symptoms include paresthesias, myalgias, muscle cramping, tetany, and convulsions.

Cinacalcet should not be administered until serum calcium levels are above 8.0 mg/dL and/or hypocalcemia symptoms are resolved.

[6][4][5] Common side effects of cinacalcet include upset stomach, vomiting, diarrhea, dizziness, nausea, weakness, and chest pain.