2HI4154413077ENSG00000140505ENSMUSG00000032310P05177P00186NM_000761NM_009993NP_000752NP_034123Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the human body.

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP1A2 localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke.

[8] 19-HETE is an inhibitor of 20-HETE, a broadly active signaling molecule, e.g., it constricts arterioles, elevates blood pressure, promotes inflammation responses, and stimulates the growth of various types of tumor cells; however the in vivo ability and significance of 19-HETE in inhibiting 20-HETE has not been demonstrated.

CYP1A2 is not regarded as being a major contributor to forming the aforementioned epoxides[12] but could act locally in certain tissues to do so.