The second was a former mansion that operated as a Marine Hospital during 1882–1905; it was later used as a water pollution field station that grew into the U.S. Public Health Service's primary environmental health research program, and the predecessor to the current Andrew W. Breidenbach Environmental Research Center.

The first hospital was completed in 1860[1] at Sixth and Lock Streets at the foot of Mount Adams to the east of Downtown.

[2] After the war, it was purchased by banker Joseph C. Butler and donated to the Sisters of Charity, a Catholic religious community, to become the location of Good Samaritan Hospital.

[8] The second hospital was originally built around 1815 as the mansion of grocery and hardware merchant David Kilgour.

It was a brick colonial structure with an ornate front porch with columns at the end of Third Street at the base of Mount Adams, and was known as the White House.